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For genotoxicity tests, various procedures are used to determine changes in the chromosome structure, gene damage, tumor-creation potential or reproduction functions that are caused by products or extracts.
To assess carcinogenity, DIN EN ISO 10993-3 compliant tests are made, which determine the tumor-creation potential of products in case of single or multiple exposures.
For reproductive and developmental toxicity tests, various procedures are used to evaluate the potential effects of test samples on reproductive function, embryonic development and prenatal and early postnatal development.
If necessary, the following methods are available:
Genotoxicity:
– in vitro test
salmonella typhimurium reserve mutation test (Ames-Test)
chromosome aberration test
mouse lymphoma test
– in vivo test
micronucleus test
Carcinogenity:
– carcinogenity studies
– combined chronic toxicity/carcinogenity studies
Reproductive toxicity:
– teratogenicity
– one-generation reproduction toxicity study
– reproduction/developmental toxicity screening tests
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